Objective
The trifunctional catalytic systems (TCS) consisting of bifunctional photocatalysts and transition metals will be designed to achieve the enantioselective N- C(sp3)-H functionalization of amides (ENCHFA). Mechanistically, the bifunctional chiral hydrogen bonding-based aryl ketones will activate the amides to form -amido radicals via HAT and control their reactivity in an enantioselective manner while transition metal will provide another opportunity to active substrates and accomplish the photocatalytic cycle via a radical relay. Combining chiral hydrogen bonding-based aryl ketones with Co catalysis, the protocol will develop the external oxidant-free enantioselective N- C-H alkenylation, arylation and alkoxylation of amides with H2 evolution. Furthermore, the enantioselective N- C-H trifluoromethylation of amides will be relized by merging chiral hydrogen bonding-based aryl ketones with Cu catalysis. The trifunctional catalytic systems will not only enrich the types of enantioselective C-H functionalization of amides, but also reveal the mechanism of trifunctional catalytic systems, as well as provide guidance for designing multiple systems in asymmetric catalysis.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80333 Muenchen
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.