Project description
Molecular insight into plant response to DNA damage
Plants are constantly exposed to environmental stressors, resulting in DNA damage and accumulation of mutations that may compromise crop yields. To counteract this damage, plants activate the DNA damage response (DDR), a mechanism that halts cell division and prevents genetic mutations from being passed on to future generations. With the support of the Marie Skłodowska-Curie Actions programme, the DELLAsFixGenome project will focus on DELLA proteins, which play a central role in regulating plant growth and responses to stress. Using Arabidopsis thaliana as a model organism, researchers will elucidate how DELLA proteins modulate DNA repair pathways during drought conditions. Project results may lead to novel approaches for cultivating plants with enhanced stress tolerance.
Objective
DNA damage represents a threat for organisms because it can generate harmful mutations in the genetic material that not only affect the individual, but can also be transmitted to the next generation. Plants are sessile organisms that are exposed to mutagenic agents, and it is a reported cause of productivity loss in crops. When DNA damage occurs, organisms trigger a signaling pathway called DNA Damage Response (DDR). The aim of DDR is the transcriptional regulation of genes related to cell cycle, endoreduplication and cell death, to limit the harm. Preliminary data obtained at the laboratory indicate that plants with low and high DELLA activity are less and more tolerant to DNA damage under stress conditions, respectively. DELLAs are important growth repressors involved in several regulatory pathways. These proteins act as regulatory 'hubs' linking environmental signals with cellular functions and coordinating growth and stress responses. In this project we propose to elucidate the mechanism by which DELLA proteins act to enhance DDR using drought stress in Arabidopsis thaliana as a study model. This will generate new knowledge about the function of DELLAs in plants, allowing the possibility of design novel tools to improve crops of agronomic interest in the future.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2023-PF-01
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28006 Madrid
Spain
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