Project description
RNA-targeting drug discovery
RNA is recognised as a versatile target for therapeutic interventions due to its crucial role in regulating gene expression and cellular functions. Several types of RNA exist which have well-defined binding sites, offering unique targets that can help address the underlying molecular causes of diseases. With the support of the Marie Skłodowska-Curie Actions programme, the TargetRNA project aims to train the next generation of scientists in the development of small molecules that bind to RNA and modulate its functions. The project will focus on antimicrobial compounds that modify the human gut microbiome.
Objective
RNA molecules play key roles in biological processes and diseases. An emerging avenue to develop innovative medicines is therefore to design small molecule drugs that bind to RNA and affect downstream biological functions. However, to advance this field of research, a new generation of scientists is needed that can further develop and ultimately master the challenging process of drug design applied to RNA. Therefore, the TargetRNA network aims to educate and nurture the next generation of scientists with cutting-edge interdisciplinary skills in the discovery and biological characterization of RNA modulators and thus generate fundamental knowledge on what drives affinity and specificity of small molecules binding to RNA. The objective of TargetRNA is to develop compounds with antimicrobial activity through their interaction with RNA targets, and to use these to selectively reshape the human gut microbiome, an area with vast implications for medicine. Training through research activities, spanning from computational and medicinal chemistry over structural and molecular biology to microbiology and in vivo models, will be supplemented by an innovative training programme in specific and transferable skills for interdisciplinary drug discovery strategies to target RNA, including FAIR data principles, open science practices as well as responsible development and sustainable implementation of new innovations. To achieve the ambitious research and training goals, the TargetRNA network unites leading scientists from 13 academic partners (8 beneficiaries, 5 associated) and 4 industry partners (1 beneficiary, 3 associated) based in 9 countries.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences genetics RNA
- natural sciences biological sciences microbiology
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2023-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5020 Bergen
Norway
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Participants (8)
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2800 Kongens Lyngby
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60323 Frankfurt Am Main
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68163 Mannheim
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06100 Nice
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16163 Genova
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151 85 Sodertaelje
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6525 XZ Nijmegen
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751 05 Uppsala
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Partners (8)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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WR14 1XZ MALVERN
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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35037 Marburg
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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4051 Basel
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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4105 Biel-Benken
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
13125 Berlin
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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SA2 8PP Swansea
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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581 83 Linkoping
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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40126 Bologna
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