Objectif THE AETIOLOGICAL AGENT OF AIDS, HUMAN IMMUNODEFIECEINCY VIRUS (HIV) IS TRANSMITTED FROM MOTHER TO A CHILD. TRANSMISSION RATES OF HIV VARY WIDELY AND SEVERAL MATERNAL FACTORS CAN INCREASE RISK OF INFECTION. THE NUMBER OF WOMEN INFECTED WITH HIVE IS INCREASING AND MAJORITY OF THESE ARE OF CHILD BEARING AGE. THERAPEUTIC AND PROPHYLACTIC INTERVENTIONS DESIGNED TO INTERRUPT TRANSMISSION OF HIV FROM AN INFECTED WOMAN TO HER NEW BORN ARE ESSENTIAL. AN UNDERSTANTDING OF THE PATHOGENESIS OF HIV INFECTION IN PREGNANT WOMAN AND INFANTS IS CRUCIAL FOR DEVELOPMENT OF THESE. CONFLICTIN INFORMATION IS AVAILABLE WITH REGARD TO THE EFFECT OF HIV ON PREGNANCY OUTCOME. TRANSPLACENTAL PASSAGE OF HIV HAS BEEN DOCUMENTED TO OCCUR AS EARLY AS 8 WEEKS OF PREGANCY. LITTLE WORK HAS BEEN DONE WITH RESPECT TO THE PATHOGENESIS AND RISK FACTORS ASSOCIATED WITH EARLY TRANSMISSION ROLE OF PLACENTA IN PERINATAL TRANSMISSION, OR PLACENTAL DYSFUNCTION ASSOCIATED WITH HIV INFECION. HUMAN TROPHOBLAST CAN BE INFECTED WITH HIV IN VITRO AND THESE CELLS CAN SUSTAIN THE WHOLE VIRUS CYCLE. IT HAS ALSO BEEN SHOWN THAT HUMAN TROPHOBLAST PRODUCES INTERFERONS WHICH MAY INFLUENCE OUTCOME OF HIV INFECTION. 1. CHARACTERIZATION OF PLACENTAL CELL TYPES WITH RESPECT OF CD4 AND HIV/SIV INFECTION. 2. STUDY THE ROLE OF TROPHOBLAST INTERFERONS IN PLACENTA WITH RESPECT TO HIV INFECTION. 3. IDENTIFICATION OF MORPHOLOGICA CHARACTERISTICS OF PLACENTA SPECIFIC FOR HIV INFECTION. THE CORRELATION BETWEEN CHORIOAMNIONITIS AND LEAKINESS OF TROPHOBLAST BARRIER IN RELATION TO VERTICAL TRANSMISSION WILL BE STUDIED. 4. TIMING OF PERINATAL INFECTION AND VERTICAL TRANSMISSION OF SIV WILL BE STUDIED IN BABOONS. LIMITED STUDIES ON THIS ASPECT WILL BE DONE IN CHIMPANZEES. Champ scientifique natural sciencesbiological sciencesmicrobiologyvirologymedical and health scienceshealth sciencesinfectious diseasesRNA virusesHIVmedical and health sciencesclinical medicineobstetrics Programme(s) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Thème(s) Data not available Appel à propositions Data not available Régime de financement CSC - Cost-sharing contracts Coordinateur DANISH CANCER SOCIETY Contribution de l’UE Aucune donnée Adresse 10,Gustav Wieds Vej 10 8000 AARHUS C Danemark Voir sur la carte Coût total Aucune donnée Participants (3) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire INSTITUTE OF TROPICAL MEDICINE PRINCE LEOPOLD Belgique Contribution de l’UE Aucune donnée Adresse 155,Nationalestraat 155 2000 ANVERS /ANTWERPEN Voir sur la carte Coût total Aucune donnée NATIONAL MUSEUMS OF KENYA Kenya Contribution de l’UE Aucune donnée Adresse 00403 KAREN Voir sur la carte Coût total Aucune donnée UNIVERSITY OF NAIROBI Kenya Contribution de l’UE Aucune donnée Adresse Kenyatta National Hospital 2 NAIROBI Voir sur la carte Coût total Aucune donnée
