Objective
THE AETIOLOGICAL AGENT OF AIDS, HUMAN IMMUNODEFIECEINCY VIRUS (HIV) IS TRANSMITTED FROM MOTHER TO A CHILD. TRANSMISSION RATES OF HIV VARY WIDELY AND SEVERAL MATERNAL FACTORS CAN INCREASE RISK OF INFECTION. THE NUMBER OF WOMEN INFECTED WITH HIVE IS INCREASING AND MAJORITY OF THESE ARE OF CHILD BEARING AGE. THERAPEUTIC AND PROPHYLACTIC INTERVENTIONS DESIGNED TO INTERRUPT TRANSMISSION OF HIV FROM AN INFECTED WOMAN TO HER NEW BORN ARE ESSENTIAL. AN UNDERSTANTDING OF THE PATHOGENESIS OF HIV INFECTION IN PREGNANT WOMAN AND INFANTS IS CRUCIAL FOR DEVELOPMENT OF THESE. CONFLICTIN INFORMATION IS AVAILABLE WITH REGARD TO THE EFFECT OF HIV ON PREGNANCY OUTCOME. TRANSPLACENTAL PASSAGE OF HIV HAS BEEN DOCUMENTED TO OCCUR AS EARLY AS 8 WEEKS OF PREGANCY. LITTLE WORK HAS BEEN DONE WITH RESPECT TO THE PATHOGENESIS AND RISK FACTORS ASSOCIATED WITH EARLY TRANSMISSION ROLE OF PLACENTA IN PERINATAL TRANSMISSION, OR PLACENTAL DYSFUNCTION ASSOCIATED WITH HIV INFECION. HUMAN TROPHOBLAST CAN BE INFECTED WITH HIV IN VITRO AND THESE CELLS CAN SUSTAIN THE WHOLE VIRUS CYCLE. IT HAS ALSO BEEN SHOWN THAT HUMAN TROPHOBLAST PRODUCES INTERFERONS WHICH MAY INFLUENCE OUTCOME OF HIV INFECTION.
1. CHARACTERIZATION OF PLACENTAL CELL TYPES WITH RESPECT OF CD4 AND HIV/SIV INFECTION.
2. STUDY THE ROLE OF TROPHOBLAST INTERFERONS IN PLACENTA WITH RESPECT TO HIV INFECTION.
3. IDENTIFICATION OF MORPHOLOGICA CHARACTERISTICS OF PLACENTA SPECIFIC FOR HIV INFECTION. THE CORRELATION BETWEEN CHORIOAMNIONITIS AND LEAKINESS OF TROPHOBLAST BARRIER IN RELATION TO VERTICAL TRANSMISSION WILL BE STUDIED. 4. TIMING OF PERINATAL INFECTION AND VERTICAL TRANSMISSION OF SIV WILL BE STUDIED IN BABOONS. LIMITED STUDIES ON THIS ASPECT WILL BE DONE IN CHIMPANZEES.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences clinical medicine obstetrics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
8000 AARHUS C
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.