Project description
Understanding the role of cellular footprints in cellular dynamics
Cell migration is crucial for development, tissue repair, and disease progression. However, the role of cellular footprints – residual cues left by migrating cells – remains unclear. With the support of the Marie Skłodowska-Curie Actions programme, the MEMOCELL project will investigate how these footprints affect memory in cell dynamics and influence behaviour within the extracellular matrix (ECM). This research is vital for advancing our understanding of cell migration and developing new therapies for diseases like cancer, in line with the EU’s Beating Cancer Plan. Recent advancements in mechanobiology and cell biology enable the precise study of these cellular memory phenomena. Ultimately, the project aims to pave the way for new therapies in migration-related diseases.
Objective
"MEMOCELL: Mechanobiological Exploration of Memory Origin in CELLular Dynamics
Cell migration is a fundamental process in development, tissue repair, and disease progression. Despite advances in understanding cellular dynamics, the role of cellular ""footprints""residual cues left by migrating cellsremains poorly understood. The goal of this proposal is to fill this knowledge gap by investigating how cellular footprints contribute to the memory effects in cell dynamics and their impact on cell behavior within the extracellular matrix (ECM). Addressing this gap is crucial, as it could redefine our understanding of cell migration and lead to innovative therapeutic strategies for diseases where cell migration is key, such as cancer.
This aligns with the EUs Beating Cancer Plan, making this research of significant societal relevance. Recent advancements in mechanobiology and cell biology now make it possible to precisely study these recently reported cellular memory phenomena. I believe in my ability to lead this project, given my multidisciplinary background in materials science, chemistry, and cell biology, and my established collaborations with leading experts in the field.
This fellowship will also be a fundamental step in my career, providing me with the expertise in advanced cell biology needed to establish myself as an independent researcher and leader in the emerging field of mechanobiology. Through this project, I aim to contribute to scientific excellence and societal well-being, while achieving my long-term goal of leading innovative, interdisciplinary research at the intersection of biology, physics and materials science."
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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91058 Erlangen
Germany
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