Project description
Mimicking nanocarriers enhancing therapeutic effectiveness in chronic inflammatory diseases
A better understanding of how nanoparticles interact with cells and their role in immunomodulation will lead to more effective therapies for chronic inflammatory diseases and advance nanomedicine. Supported by the Marie Skłodowska-Curie Actions programme, the NANO-MAC project will develop macrophage-mimicking nanocarriers (MMCs) with fusogenic properties (FMMCs) for targeted delivery of dexamethasone to inflammation sites, focusing on inflammatory bowel disease (IBD). These nanocarriers aim to enhance therapeutic effectiveness while minimising systemic side effects. The project will synthesise and optimise MMCs for better drug delivery, evaluating their biocompatibility, cytotoxicity, and immune response modulation. FMMCs will also be tested in an in vitro model for effectiveness.
Objective
"Parkinsons disease (PD) is a progressive neurodegenerative disorder that affects over 10 million individuals globally. Tremors, which are the most prevalent symptom, afflict approximately 80% of PD patients. These tremors can significantly hinder daily activities such as eating, dressing, and washing, among others, and can also impose a substantial psychological burden on the affected individuals. Consequently, suppressing tremors in PD patients is crucial for enhancing their quality of life and alleviating psychological stress. In response to this need, Dr Guohui Wang, an experienced researcher from Shanghai University in China, moving to the University of Exeter in the United Kingdom to collaborate on the project titled ""New-generation wrist exoskeleton with variable stiffness and optimized biomechanics for tremor suppression (NextTremor)"" under supervision of Dr Xijin Hua and Prof. Marios Politis. The objective of this project is to design and develop an innovative, lightweight, and cost-effective 3D-printed wrist exoskeleton with adjustable stiffness, which facilitates personalization and optimizes biomechanics for the effective suppression of tremors of varying intensities. The project will leverage the fellow's expertise in mechatronics, sensors, wearable devices, and 3D printing, in conjunction with the primary supervisor's proficiency in musculoskeletal modelling and human movement analysis, and will be further supported by the secondary supervisor's specialized knowledge in PD. Thus, this initiative seeks to establish a knowledge-sharing platform that enables the fellow to acquire new skills while fostering the exchange of expertise between the fellow and the host in the domains of biomechanics, musculoskeletal modelling, human movement analysis, mechatronics, sensors, wearable devices, 3D printing, and Parkinson's disease."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology mechanical engineering mechatronics
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- natural sciences biological sciences biophysics
- medical and health sciences basic medicine neurology neurodegenerative diseases parkinson
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
EX4 4QJ Exeter
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.