Project description
Saliva biomarkers for sepsis diagnosis
Sepsis is a life-threatening condition caused by an overwhelming immune response to infection. It carries a mortality rate of around 26 %, underscoring the importance of early diagnosis. However, there are no reliable biomarkers available. With the support of the Marie Skłodowska-Curie Actions programme, the SepBiEV-D project is investigating extracellular vesicles (EVs) as a new source of sepsis biomarkers. EVs are tiny particles released by cells as a means of intercellular communication. To identify potential biomarkers, researchers will employ a canine model of human sepsis and undertake protein and metabolite profiling. Project results are expected to improve antibiotic stewardship and ultimately enhance survival in both veterinary and human medicine.
Objective
Sepsis, the organ dysfunction triggered as a consequence of deleterious inflammatory host response to infection, has a 26% mortality rate in humans. However, there is a lack of reliable biomarkers for its accurate diagnosis. Extracellular vesicles (EVs) are small particles naturally released from the cells with promising applications in diagnosis and disease monitoring.
This Project aims to evaluate salivary and serum EVs as sources of novel biomarkers in a naturally occurring model of sepsis using a multidisciplinary approach. For this, canine pyometra, a naturally occurring animal model for human sepsis, will be used. Different isolation methods for EVs and their subpopulations will be evaluated, and the most feasible will be selected. Isolated EVs will be characterized using proteomics, metabolomics, and biochemical analyses. Last, the quantity and characterization of EVs will be compared between dogs meeting sepsis criteria and those obtained from healthy individuals and animals with inflammation. This would point out different biomarkers of sepsis to be further evaluated.
The results of this Project would help improve sepsis diagnostics, which can highly increase patient survival and promote adequate use of antibiotics, ultimately fighting against antimicrobial resistance. Plus, it will support using saliva as a non-invasive sample for sepsis diagnosis. Last, it is expected that the sepsis biomarkers identified in this Project could be extrapolated to other species, including humans.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- social sciences sociology demography mortality
- agricultural sciences animal and dairy science domestic animals
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
10000 Zagreb
Croatia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.