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Stress-Induced Preconditioning for Resilient Engineered Living Materials in Probiotic Architecture

Project description

Stress-triggered preconditioning for resilient engineered living materials

Buildings provide shelter and community spaces but often rely on materials that harm the environment. Sustainable methods that use eco-friendly materials can reduce this impact. Engineered living materials (ELMs) offer a regenerative alternative by introducing living systems in construction, and research indicates that mild stress can strengthen biological resistance to future stressors. Supported by the Marie Skłodowska-Curie Actions programme, the PRO-TECTURE project will enhance the resilience and performance of ELMs by preconditioning living fungal cells (biofilms) with abiotic stress. It will explore stress memory, communication between fungi through secreted molecules, and possible interactions with human cells. By incorporating ELMs into building practices, the project aims to reduce environmental impacts, promote restoration and improve human health in the building sector.

Objective

Buildings are an essential part of human life, providing shelter, spaces for work, and hubs for community activities. However, conventional construction methods have a big negative impact on the environment. To achieve sustainability, alternative approaches using natural and environmentally friendly materials, such as wood, are being employed. Regenerative sustainability takes this a step further, not only by minimizing harm but also by creating a net positive impact on both the environment and the community. Engineered living materials (ELMs) represent an innovative frontier in realizing regenerative sustainability. The aim of PRO-TECTURE project is to develop more resilient and efficient ELMs by preconditioning living fungal cells (biofilm used as ELM) with abiotic stress. Previous research has shown that exposure to mild stress can trigger adaptive responses, preconditioning biological systems to be more resilient to future stressors. The PRO-TECTURE project will use stress preconditioning to enhance the resilience of ELMs, investigating the existence and duration of stress memory, as well as intraspecies stress communication through secreted molecules. Furthermore, given the ER’s background in biomedicine, the project will explore the possibility of interkingdom stress communication between pre-stressed fungi and human cells. By integrating ELMs into building practices, it is anticipated that these structures will not only minimize negative environmental impacts but also actively contribute to environmental restoration and enhance human well-being and health in the built environment. The PRO-TECTURE aims to stimulate innovation and facilitate knowledge transfer between the host and the ER by establishing a robust research network, organizing events, mentoring young researchers, and managing projects. Through this fellowship, the ER will gain advanced research and scientific skills, acquiring new competencies to achieve professional maturity and independence.

Fields of science (EuroSciVoc)

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2024-PF-01

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Coordinator

UNIVERZA NA PRIMORSKEM UNIVERSITA DEL LITORALE
Net EU contribution
€ 182 717,52
Address
TITOV TRG 4
6000 Koper
Slovenia
Region
Slovenija Zahodna Slovenija Obalno-kraška
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data