Project description
Mapping hippocampal signals in early life
The majority of cognitive disorders begin during early brain development, yet the underlying mechanisms of neuromodulatory systems remain poorly understood. Patterns of activity during early life organise memory and learning circuits in the hippocampus, with noradrenaline centrally implicated. Supported by the Marie Skłodowska-Curie Actions programme, the HIPPNADEV project aims to use mice to trace the emergence of noradrenaline transmission in the hippocampus at the circuit and cellular levels. It will combine spatial transcriptomics with in vivo imaging of neuronal activity and noradrenaline release. Comparing healthy brains and schizophrenia-model brains, HIPPNADEV hopes to uncover mechanisms of hippocampal development. The expected outcomes offer new directions for the treatment of neurodevelopmental disorders.
Objective
Many brain disorders with cognitive impairment originate during development, when synaptic and neuromodulatory circuits progressively emerge, mature and give rise to function. In the hippocampus, stereotyped sequences of brain activity patterns in early life are thought to set the stage for coherent cognitive and memory processes in adulthood, for which noradrenaline neuromodulation is also critical. However, surprisingly little is known about the developmental origins of hippocampal neuromodulation in general, and of noradrenaline transmission in particular, neither in health nor disease.
In project HIPPNADEV, I will investigate the contribution of noradrenergic transmission to the post-natal development of the hippocampus: In other words, “if”, “when” and “how” noradrenergic signals acquire their cellular and circuit-level properties in the developing hippocampus. I will use a highly innovative, translationally relevant, multi-disciplinary and multi-scale approach, combining in mice anatomical and functional interrogation using cutting-edge technology including spatial transcriptomics and in vivo all-optical dual imaging of noradrenaline release and single-neuron calcium activity. Further, this project will compare the developmental trajectories and functional significance of hippocampal noradrenergic signals at baseline and in rodent models of schizophrenia.
Altogether, it will significantly advance our understanding of hippocampal neurodevelopment on one hand – implicating neuromodulatory noradrenergic transmission therein – and vice versa elucidate still-unknown developmental aspects of noradrenaline transmission. Such breakthroughs will offer promising bases for future fundamental study of the neuromodulatory correlates of neurodevelopment, as well as a solid preclinical framework to better combat schizophrenia syndromes and associated psychoses.
Fields of science (EuroSciVoc)
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- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- medical and health sciences clinical medicine psychiatry schizophrenia
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2024-PF-01
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75654 Paris
France
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