Project description
Kinetic biosensors for continuous monitoring in diabetes treatment
Continuous monitoring has revolutionised diabetes treatment by providing real-time blood sugar feedback. However, developing constant monitoring biosensors for other biomarkers remains challenging due to the slow dissociation kinetics of many recognition elements, resulting in time lags and inaccurate concentration measurements. Supported by the Marie Skłodowska-Curie Actions programme, the CIFS project aims to advance continuous monitoring through the kinetic programming of biosensors. It will design a universal sensing architecture that improves CMB performance by accelerating the binding and unbinding of bioreceptors and analytes. By incorporating nature-inspired regulatory strategies, such as the induced fit mechanism, the project seeks to enable precise and rapid biomarker monitoring in clinical settings.
Objective
The advent of continuous monitoring has transformed the treatment of patients with chronic diseases such as diabetes, offering real-time information on their blood sugar levels. Nevertheless, the advancement of continuous monitoring biosensors (CMB) for additional biomarkers beyond glucose is impeded by the slow dissociation kinetics of numerous recognition elements utilised in CMB, resulting in time lags and erroneous determination of concentrations. This proposal aims to address this universal problem in continuous monitoring by shifting the focus to the kinetic programming of biosensors. In particular, my goal is to develop a novel and universal sensing architecture that will enhance the performance of CMB by accelerating the binding and unbinding events between a bioreceptor and its analyte. To this end, I will leverage my foundational work on nature-inspired regulatory strategies to implement the induced fit (IF) strategy in CMB. This innovative approach has the potential to markedly enhance the performance of CMB for a diverse array of sensing applications, facilitating more precise and rapid monitoring of biomarkers in a multitude of clinical settings.
This fellowship built on my background in fundamental chemistry, leveraging my experiences in exploring new concepts for biosensing using DNA-based models and combining that with the recognized expertise in synthetic biology, protein engineering, and biosensors of Prof. Maarten Merkx at Eindhoven University of Technology (TU/e, Netherlands).
In addition to the research component, this fellowship will provide me with transferable skills that are essential for a successful academic career, including proposal writing, student supervision, leadership, and event organization. The research opportunities and professional development offered by this fellowship would be invaluable in helping me establish myself as an independent and successful principal investigator.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
- engineering and technology environmental biotechnology biosensing
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine endocrinology diabetes
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.