Project description
The physics behind wing development in flies
Understanding morphogenesis, how tissues and organs acquire their 3D structure, is a central question in biology. This involves the interplay between genetic, biochemical and physical factors, but the physical mechanisms orchestrating these changes remain poorly understood. With the support of the Marie Skłodowska-Curie Actions programme, the 3D-MEMorpho project aims to shed light on how epithelial tissues, such as those forming the wings of the fruit fly Drosophila, undergo shape transformation during development. Researchers will combine theoretical models, numerical simulations and experimental data to dissect the interactions among genes, hormones and mechanical forces. Project findings could provide new insights into tissue engineering and developmental biology.
Objective
How the organismal morphology is specified, maintained, and evolving is an intriguing open question of developmental biology and biophysics. In this proposal, I aim to unravel the physical mechanisms underlying the three-dimensional (3D) morphodynamics of epithelium. Drosophila wing disc is a good model organism for this problem because it undergoes complex 3D morphogenetic processes from larval to pupal stage which are highly related to gene expression, hormone level, cell active behaviors, and mechanical forces. The correct sequential folding, unfolding, and eversion of wing disc have been observed as exquisite and elaborated processes while the underlying physical mechanism is still unclear.
We will establish a biomechanical theoretical framework with a novel hybrid vertex-continuum model, and develop advanced numerical simulation methods to mimic wing disc three-dimensional morphodynamics. A morphometric analysis method and statistical quantifications will be developed and applied, for the first time, to quantitatively compare the simulation and experiments performed by my collaborators.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80539 MUNCHEN
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.