Project description
New open-source tools could deliver patient-specific diagnostics within seconds
Cardiovascular diseases remain the leading global cause of death. As risk factors rise so does the demand for better diagnostics and treatments. While computational fluid and solid mechanics offer valuable insights into the circulatory system, they are often too slow for clinical use. With the support of the Marie Skłodowska-Curie Actions programme, the VascularROM project aims to develop reduced order models for the vascular system that can be adapted to individual patients. Researchers will develop suitable physics models that account for anatomical differences and complex blood-tissue interactions. Notably, these models will provide critical biomarkers in seconds. Beyond healthcare, VascularROM will empower the computational science and engineering community by offering open-source tools, modern finite element codes and tutorials.
Objective
Cardiovascular diseases are the leading cause of death globally, and risk factors for numerous pathologies of the circulatory system are continuously increasing. Medical treatment options and diagnostics improve, where especially the recent advances in data-driven numerical methods for clinical support bear great potential. Computational fluid and solid mechanics play a key role in gaining insight into the complex physics, but even highly efficient traditional schemes do not fit into the clinical timeframe.
This project aims to develop reduced order models targeting the vascular system, considering for inter-patient variability. Following this approach, a compute-intense offline phase constructs suitable physics-consistent surrogate models, which deliver faithful approximations in near-real-time to be queried by the user in the online phase. The state of the art in model order reduction of the vascular system is extended by considering for global geometric variability, advanced material models and parameter fields for blood and tissue as well as their coupling to derive patient-specific biomarkers of clinical relevance within seconds.
These developments will not only open the path to transforming the role of numerical modeling in clincial practice, but will further build a starting point for the computational science and engineering community by providing open-source implementations based on highly efficient, modern finite element codes and accompanying tutorials to foster future developments and initiate momentum.
The proposed project encompasses an outgoing phase at the Oden Institute, UT Austin, where the ambitious project goals are persued together with advisors Prof. K.E. Willcox and Prof. T.J.R. Hughes, two of the most influential experts in computational science and engineering. The developed reduced order models are then further tailored to the clinical scenario at TU Graz’s Institute of Biomechanics, validating their applicability.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-GF - HORIZON TMA MSCA Postdoctoral Fellowships - Global Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8010 Graz
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.