Project description
Mechanisms behind continuous transmission of SARS-CoV-2 during COVID-19 reinfections
Viral infections can re-occur when immune protection fails to prevent virus reinvasion. With SARS-CoV-2, reinfections have emerged as a critical concern during the evolving COVID-19 pandemic as transmission of the virus could occur even in vaccinated people. Understanding host-virus interactions across respiratory viral infections is central to the design of novel therapeutics and for public health and pandemic preparedness. With the support of the Marie Skłodowska-Curie Actions programme, the INSIDER-CoV project will investigate the immune dynamics of SARS-CoV-2 reinfection. Using a hamster model of the disease, researchers aim to refine current knowledge of reinfections and elucidate the factors that determine reinfection susceptibility and body response to repeated exposures. The aim is to understand how the virus can still be transmitted in immuno-competent people.
Objective
INSIDER-CoV: Investigating Nasal and Systemic Immune Dynamics during SARS-CoV-2 Reinfections
The global challenge posed by COVID-19 necessitates a profound understanding of SARS-CoV-2, particularly concerning the phenomenon of reinfections. The INSIDER-CoV project seeks to address this critical gap by employing the Syrian golden hamster model, which has previously demonstrated its efficacy in primary infection studies. Central to this research is a meticulous exploration of the immune response within the nasal cavity, the primary gateway for the virus. By comparing this localized immune reaction to the broader systemic response, the project aims to shed light on the determinants of reinfection susceptibility and the intricacies of host-virus interactions during repeated exposures.
The urgency and relevance of this investigation are paramount. As the dynamics of the pandemic continue to evolve, the potential for reinfections emerges as a pressing concern. Through rigorous investigation, INSIDER-CoV endeavors to refine the previous knowledge about SARS-CoV-2 reinfections, offering insights that could lead to the development of novel therapeutic interventions and preventive measures. While rooted in academic research, the implications of this study have the potential to influence pharmaceutical developments and inform public health directives on a global scale.
Furthermore, the scope of INSIDER-CoV extends beyond the immediate crisis. By considering the broader context of potential respiratory pandemics in the future, the project ensures its relevance and applicability in the long term. In summary, INSIDER-CoV represents a pivotal step in the scientific community's ongoing efforts to combat current and future viral challenges. Through meticulous research and collaboration, this project aims to significantly contribute to the global understanding of viral infections and their broader implications.
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Keywords
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75007 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.