Project description
New blood test for early detection and staging of Alzheimer’s disease
Tau is a protein that stabilises neuronal cells, but in Alzheimer’s disease (AD), it becomes abnormally modified, forming tangles that disrupt brain function. The detection of specific, disease-associated forms of Tau in blood or cerebrospinal fluid has emerged as a promising avenue for diagnosis of AD at an early stage and for monitoring disease progression. With the support of the Marie Skłodowska-Curie Actions programme, the TAMBO-AD project aims to develop ultra-sensitive tests to detect Tau proteoforms that are simultaneously phosphorylated at two distinct sites. Researchers will validate these biomarkers in patient samples and proceed with developing portable, easy-to-use formats. The project has the potential to advance AD diagnosis in underserved regions.
Objective
Alzheimer's disease (AD) is the major cause of dementia. The disease has an escalating impact on public health due to an increasing prevalence among the aging population in Europe and globally. In light of the first disease-modifying therapies becoming available, early diagnosis and precise disease staging are crucial for timely implementation of the treatment strategy. In TAMBO-AD, I will build on my preliminary findings to leverage AD biomarker potential of tau simultaneously phosphorylated at two distinct sites. By combining my expertise in immunoassay development with the top technology available at the host institution, I will develop three novel Single Molecule Array (Simoa®) assays targeting p-tau217&231, p-tau205&217, and p-tau205&231. Through cerebrospinal fluid and plasma measurements in the Amsterdam Dementia Cohort, I will evaluate performance of all three p-tau forms as: 1) early diagnostic and 2) disease-staging biomarkers. For the best-performing plasma biomarkers, I will translate Simoa® assays into innovative fiber optic nanogold-linked immunosorbent assay format (FONLISA), which enables point-of-care testing. New point-of-care testing assays will maximize biomarker testing accessibility, enabling use in primary care centers and in remote or resource-limited areas. Finally, I will communicate the project and disseminate results in English and Polish during an intersectoral secondment at the patient organization — Alzheimer Europe. The TAMBO-AD project represents a pivotal opportunity to advance my research, grow professional network, and gradually become an independent researcher.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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1081 HV Amsterdam
Netherlands
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