Project description
A nanoplatform for stroke recovery
A stroke occurs when blood flow to a part of the brain is interrupted or reduced, depriving brain tissue of oxygen and nutrients. Depending on the affected area of the brain, this can lead to difficulties with movement, speech, memory or other bodily functions. Recovery usually involves a multidisciplinary rehabilitation approach aiming to restore neuronal damage. With the support of the Marie Skłodowska-Curie Actions programme, the NeuroNzyme project proposes to develop a non-invasive device that stimulates brain repair. This innovation is based on nanoparticles that generate microcurrents to activate neural regeneration. They also offer neuroprotective effects by regulating damaging reactive oxygen species and preserving enzyme activity.
Objective
The NeuroNzyme project represents a pioneering effort to develop a cutting-edge, self-powered, and non-invasive nanoplatform designed to enhance stroke recovery through electrical stimulation and neuroprotective therapy. At the heart of this innovation is a dual-function nanoparticle that combines the roles of both a nanoelectrode and a nano-enzymatic biofuel cell. The core of this novel approach lies in the nanoparticle's ability to generate microcurrents through a process involving the collective action of thousands of these particles surrounding neurons. This electrical stimulation activates voltage-gated ion channels on the neurons, which plays a critical role in promoting the regeneration of nervous tissue following a stroke. By continuously providing these microcurrents, the nanoparticles help facilitate the repair and rebuilding of damaged neural pathways.
These nano-enzymatic biofuel cells are powered by physiological fluids within the body. As they operate, they also offer a neuroprotective antioxidant effect by regulating the levels of reactive oxygen species (ROS). ROS are highly reactive molecules that can contribute to further neuronal damage if not properly controlled. By managing ROS levels, the nanoparticles help to protect neurons from oxidative stress, thereby contributing to a more favorable environment for recovery.
Moreover, the nanoparticles are engineered with a specific enzymatic tandem embedded within a specialized nanogel. This nanogel features a deep eutectic solvent interpenetrated network, which is crucial for maintaining high enzymatic activity over extended periods. The deep eutectic solvent enhances the stability and efficiency of the enzymes, ensuring that the nano-enzymatic biofuel cells remain effective in generating electrical stimulation and providing antioxidant protection.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48940 Leioa
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.