Project description
Spatial complexity of metastatic niches
Metastasis is a complex biological phenomenon that involves the dynamic interaction between tumour cells and their surrounding environment. At the same time, the metastatic niche must be conducive to tumour growth, with paracrine signalling and metabolic factors playing significant roles. However, our understanding of these niches remains incomplete particularly due to the lack of spatial molecular data. With the support of the Marie Skłodowska-Curie Actions programme, the spaXio project will study metastatic niches through spatial multi-omics, tumour models, and computational methods. The consortium will offer multidisciplinary training to doctoral candidates that also involves the analysis of different tumour types and organs. Ultimately, the team aims to elucidate the mechanisms driving metastasis and to identify novel therapeutic targets.
Objective
Metastasis, the leading cause of cancer-related deaths, arises from the spread of cancer cells to distant organs, where they compromise normal organ function. Cellular interactions, paracrine factors, and the metabolic environment promote the formation of metastatic niches that facilitate tumour cell survival and proliferation. While single-cell data have improved our understanding of tumours and their heterogeneity, our knowledge of metastatic niches is still very incomplete. In particular, the lack of spatial context makes it difficult to address critical knowledge gaps in metastatic niche biology which limits our progress in the development of targeted therapeutic interventions.
The doctoral network spaXio aims to tackle this challenge by training doctoral candidates (DCs) in cutting-edge techniques, including spatially resolved multi-omics, advanced tumoroid modelling, and computational approaches, including bioinformatics and AI-based prediction models. DCs will conduct systemic analyses of metastatic niches across diverse organ systems and tumour types to improve our understanding of metastatic niche formation and uncover novel therapeutic targets. SpaXio provides comprehensive, multidisciplinary training that combines hands-on laboratory experience, computational data integration, and (industry) secondments. Regular cross-disciplinary workshops and seminars boost innovation and collaboration, while transferable skills training encompasses communication, ethical research, open science, entrepreneurship, and sustainability. By partnering with a network of leading European and international academic, clinical, and industrial experts, spaXio ensures that DCs are exposed to diverse research environments and approaches. This fosters their ability to think across borders, advance technologies and integrate multiple large datasets into a complete systemic picture, preparing them to be leaders in cancer research and shape the rapidly evolving field of spatial biology.
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Keywords
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN-JD - HORIZON TMA MSCA Doctoral Networks - Joint Doctorates
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5020 Salzburg
Austria
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Participants (6)
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13284 Marseille
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80333 Muenchen
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72074 Tuebingen
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28006 Madrid
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75654 Paris
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27200 Vernon
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Partners (12)
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13007 Marseille
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94566 Pleasanton
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1015 LAUSANNE
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65760 Eschborn
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75014 Paris
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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51429 Bergisch Gladbach
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5412 Urstein bei Hallein
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1070 Wien
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01752 Marlborough
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91190 SAINT-AUBIN
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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28049 Madrid
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1011 Lausanne
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