Project description
Revolutionary accurate and precise chirality detection
Chirality is the asymmetry between a molecule and its mirror image, essential for metabolic reactions and protein stability in living organisms. Abnormal chirality can indicate various diseases, including brain and kidney disorders, as well as cancer. However, its detection and monitoring are challenging and require high precision. With the support of the Marie Skłodowska-Curie Actions programme, the TRILOGY project aims to develop a revolutionary interface in the emerging field of ultrafast chirality, utilising attosecond electronic responses to light to detect chirality and abnormal chirality precisely, accurately and rapidly. The use of ultrafast electron dynamics is designed to allow them to overcome previous limitations and enable the development of key ultrafast spectroscopies.
Objective
TRILOGY establishes the interface between the emerging field of Ultrafast Chirality and its Life and Technology applications by using attosecond electronic response to light, the fastest agent in mediating electric signals, highlighted by the 2023 Physics Nobel Prize.
Chirality, a dissymmetry between a molecule and its mirror image, is a synonym of life: it enables metabolic reactions and stability of proteins. Abnormal chirality is an indicator for cancer cells, brain or kidney diseases, but its accurate detection requires a combination of high precision and speed, where attosecond response to light gives clear advantage to optical methods. Standard chiro-optical methods are fundamentally limited in accuracy by a ratio of molecular size to the light wavelength. Resolving ultrafast electron dynamics we remove this limitation and break into a new regime with chiral signals outperforming standard methods by several
orders of magnitude. We will take advantage of this paradigm shift in chiral measurements and develop new efficient ultrafast spectroscopies for discriminating medium sized chiral biomolecules and elucidating charge and spin transport in chiral media at the most fundamental level: the level of electrons. We overlap the training and innovation landscapes in a unique way inspired by a common drive to bring cutting-edge scientific developments to applications, enabled by strong involvement of industry. We will (i) integrate our methods with existing analytics for quick market adaptation, working with the market leader for mass spectrometry
(ThermoFisher), (ii) further them to unprecedentedly high throughput enabled by laser technology (Amplitude) and state-of-the-art imaging (PIimaging). We will make a difference, motivate and inspire young minds, training a new generation of researchers at the interface of fundamental science, technology and high-tech industry to bring cutting edge research through industrial applications to the benefit of the society.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
- natural sciences chemical sciences analytical chemistry mass spectrometry
- natural sciences physical sciences optics laser physics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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12489 Berlin
Germany
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Participants (10)
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20148 Hamburg
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75794 Paris
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4000 LIEGE
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00185 Roma
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7610001 Rehovot
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28199 Bremen
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SW7 2AZ London
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22100 Lund
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EH14 4AS Edinburgh
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91120 Palaiseau
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Partners (18)
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1211 Geneve
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1015 LAUSANNE
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33600 Pessac
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7522 LL Enschede
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NG7 2RD Nottingham
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91190 SAINT AUBIN
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7522 NB Enschede
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14197 Berlin
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5504DR Veldhoven
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32000 Haifa
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34125 Kassel
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6020 Innsbruck
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80539 MUNCHEN
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10623 Berlin
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20133 Milano
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33000 Bordeaux
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1015 Lausanne
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91190 Gif-Sur-Yvette
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