Project description
Understanding yeast cell death under industrial conditions
Yeasts are model organisms in cell biology and are used for the sustainable production of compounds. They can undergo regulated cell death (RCD), which negatively affects industrial yields. However, the mechanisms of this process remain poorly understood. With the support of the Marie Skłodowska-Curie Actions programme, the UPsYDe project aims to study yeast cell death under industrial conditions and engineer RCD pathways and process conditions to enhance production. It will train doctoral candidates focusing on four yeast species: Saccharomyces cerevisiae, Komagataella phaffii, Yarrowia lipolytica and Debaryomyces hansenii, involving both start-ups and major biotechnology industries. Expected outcomes include new rapid screening techniques for cell death, advanced metabolic models, improved yeast strains and more sustainable bioprocesses.
Objective
Yeasts are model organisms for eukaryal cell biology studies but are also used to sustainably produce a large variety of compounds. Although unicellular, death spares no one and yeast can undergo regulated cell death (RCD) in response to a wide variety of intra and extracellular signals. In industrial processes, the occurrence of yeast RCD negatively impacts yields and production rates. How yeast cells die under these conditions is however hardly studied nor understood. UPsYDe aims to decipher how yeast cells die under industrial conditions and engineer RCD pathways to postpone cell death and improve production, while simultaneously training the 13 doctoral candidates needed to tackle this kind of challenges. This requires a synergetic approach combining fundamental cell biology, bioprocess engineering, yeast physiology, and systems and synthetic biology. Four different yeast species, Saccharomyces cerevisiae, Komagataella phaffii, Yarrowia lipolytica and Debaryomyces hansenii, will be studied and engineered in a consortium of 7 beneficiaries and 15 associated partners varying from start-up companies to major biotechnology industries. This consortium offers all the expertise and methodology needed and provides the DCs with a highly diverse, multidisciplinary and intersectorial training plan across Europe. Expected outcomes are novel (rapid) screening techniques to detect cell death phenotypes on site, advanced genome-scale metabolic models, improved yeast strains and more sustainable and profitable yeast bioprocesses. In addition, UPsYDe will deliver the next-generation scientists capable of integrating different knowledge fields to lead the full transition to a sustainable bioeconomy, in academia or industry.
Fields of science (EuroSciVoc)
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CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences synthetic biology
- natural sciences biological sciences cell biology
- social sciences economics and business economics bioeconomy
- medical and health sciences basic medicine physiology
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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6708 PB Wageningen
Netherlands
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Participants (6)
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4704 553 Braga
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8010 Graz
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2800 Kongens Lyngby
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SW7 2AZ London
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412 96 Goteborg
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20126 Milano
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Partners (16)
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1180 Wien
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1000 Ljubljana
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12618 Tallinn
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08028 Barcelona
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10117 Berlin
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4800 MG Breda
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2613 AX Delft
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4715-330 Braga
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31400 Toulouse
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59700 MARCQ EN BAROEUL
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53359 Rheinbach
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2880 Bagsvaerd
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2100 Copenhagen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1010 Vienna
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31270 901 Belo Horizonte Minas Gerais
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13083-872 CAMPINAS SP
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