Project description
Multiscale approach to thrombosis and personalised treatment
Blood clots, or thrombosis, cause one in four deaths worldwide. They result in strokes, heart attacks, and venous blockages. Knowing how clots form, grow, or break apart is essential to predict outcomes and customise treatments. Supported by the Marie Skłodowska-Curie Actions programme, the ThromboRisk project aims to train doctoral candidates to study thrombosis at various levels. Specifically, it will combine computer models, lab experiments, and clinical data. The project will develop tools to improve individualised prognosis and therapies. It will also prepare researchers to tackle complex health issues with innovative solutions that benefit society.
Objective
"Thrombosis, an occlusive blood clot, underlies ischemic stroke, myocardial infarction, and venous thrombosis, causing 1 in 4 deaths globally. Its incidence is rising due to an increasingly aging population and increased cardiovascular diseases, along with more cardiovascular implants. Unfortunately, limited understanding of thrombus formation, growth, and rupture hampers patient-specific prognosis. Current treatment strategies include antithrombotic therapy and thrombectomy, but improvements are needed for patient-specific treatments due to common recurrence and unknown impacts on clot fragmentation and thromboembolism.
To effectively understand disease mechanisms and accurately predict treatment outcomes, it is crucial to integrate knowledge across multiple scales, harnessing a diverse range of cutting-edge in silico, in vitro, and in vivo technologies. This powerful fusion of emerging technologies holds the potential to revolutionize targeted and personalized medicine. However, there remains a significant shortage of trained professionals capable of co-creating such comprehensive and holistic disease models.
ThromboRisk will therefore train 18 exceptional doctoral candidates (DCs) in diverse scientific fields, including mechanobiology, biochemistry, pathophysiology, and modeling. These researchers will collaborate within an international and interdisciplinary consortium to develop a platform advancing our understanding of thrombosis across scales, hereby bridging the gap between micro-level thrombus processes and macro-level impacts on disease prognosis, enabling clinical application.
Unlike traditional engineering curricula, which address well-defined problems, ThromboRisk tackles complex, multifactorial ""wicked problems"" in fields of thrombosis by implementing a Challenge-Based Learning (CBL) doctoral training program to foster creativity, innovation, and societal impact. CBL is growing in undergraduate education but remains underdeveloped in doctoral training, where it has the potential to encourage DCs to step outside their comfort zones, think creatively, manage risks, and use technology responsibly in problem-solving. The DCs will work on real-world problems with peers, supervisors, consortium members, and external stakeholders, who act as ""real clients"" and co-creators."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine physiology pathophysiology
- medical and health sciences basic medicine neurology stroke
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-DN-01
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5612 AE Eindhoven
Netherlands
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Participants (8)
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6200 MD Maastricht
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1012WX Amsterdam
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3000 Leuven
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10117 Berlin
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WC1E 6BT London
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500036 BRASOV
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30-054 KRAKOW
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LS2 9JT Leeds
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Partners (9)
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3012 Bern
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1081 HV Amsterdam
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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NW3 2QG London
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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062204 BUCURESTI
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6340 Baar
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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OX1 2JD Oxford
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6229 HX Maastricht
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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S10 2TN SHEFFIELD
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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5623EJ Eindhoven
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.