Project description
Early cancer detection with light-based tools
To improve the clinical outcome of cancer patients, it is important that we detect the disease early. However, current diagnostic tools can be invasive, expensive, or lack the required sensitivity for early detection. Light-based technologies offer a promising alternative because they can be used to examine biological tissues without causing any damage. With the support of the Marie Skłodowska-Curie Actions programme, the MHD PCF SPR Sensor project will develop a new optical fibre sensor designed to distinguish between healthy and cancerous cells. Using a specially engineered fibre with a twisted structure, the sensor increases the interaction between light and biological samples, allowing very small differences in cell characteristics to be detected.
Objective
This research presents a novel photonic crystal fiber (PCF) based surface plasmon resonance (SPR) sensor featuring a multi-helical dual-faced design, reported for the first time. The sensor enhances light-matter interaction (LMI) through its unique geometry, with different arrangements of air holes at both ends and a twisted intermediate section. This geometry optimizes sensitivity for detecting cancerous cells, with the refractive index (RI) of cancerous cells ranging from 1.36 to 1.42 RIU. The proposed sensor employs SPR technology, with plasmonic coatings such as gold (Au) and silver (Ag) to improve light confinement and signal strength. Additionally, reflectance spectroscopy is integrated to further enhance the diagnostic capabilities, enabling precise surface-level and sub-surface imaging of biological tissues, crucial for early cancer detection. The twisted design of the PCF alters electromagnetic field distribution, allowing for precise control of light propagation, polarization, and intensity, making it highly effective in distinguishing between healthy and cancerous tissues. The internal twisted region enhances LMI and reflectance characteristics, offering high-resolution imaging, ideal for detecting subtle changes in tissue structures. This sensor’s versatility extends beyond cancer detection, finding potential applications in environmental monitoring, chemical sensing, and communication systems. Theoretical modeling and computational simulations demonstrate the sensor's ability to detect minute variations in commercially available cancer cell fluids with high specificity and accuracy. Combining SPR and reflectance spectroscopy in this innovative design marks a significant advancement over traditional fiber-optic sensors. The results showcase its potential for use as a powerful diagnostic tool in oncology, particularly in early-stage cancer detection, while also offering broader applications in fields requiring high-precision detection, imaging and sensing
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2024-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
01513 Vilnius
Lithuania
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.