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Wearable Hybrid Interfaces of Smart Printable Engineered Responsive nanomaterials enabling real-time cfDNA sensing for early diagnosis

Project description

Simplifying cancer monitoring through wearable technology

Innovative wearable technology has the potential to transform cancer detection and monitoring. Unlike traditional methods that rely on slow and expensive laboratory techniques, this technology offers a real-time, low-cost solution for tracking cancer-related circulating cell-free DNA (cfDNA) in the bloodstream. These fragments of genetic material released by cancer cells can help doctors in early diagnosis, treatment tracking and relapse monitoring. Supported by the Marie Skłodowska-Curie Actions programme, the WHISPER project will combine smart nanomaterials, which selectively bind to cfDNA, with electrochemical sensors that convert this interaction into electronic signals. Flexible, printable electronics will ensure that the patch is comfortable for continuous wear. The proposed patch paves the way for more accessible care while advancing Europe’s goals in precision medicine and digital health.

Objective

Cancer leaves tiny fragments of genetic material, called circulating cell-free DNA (cfDNA), in the blood. Detecting these fragments can help doctors spot cancer earlier, track treatment, and monitor relapse. Today, tests for cfDNA rely on lab-heavy methods like PCR or sequencing, which are slow, expensive, and unsuitable for regular monitoring. The WHISPER (Wearable Hybrid Interfaces of Smart Printable Engineered Responsive nanomaterials enabling real-time cfDNA sensing for early diagnosis) project aims to change this by creating a wearable patch that can track cancer-related cfDNA in real time, directly on the body. This device combines smart nanomaterials that selectively capture cfDNA, tiny electrochemical sensors that turn this binding into an electronic signal, and flexible, printable electronics for comfortable skin wear. Unlike current tests, WHISPER works without complex equipment or sample processing, offering a continuous, low-cost, and patient-friendly alternative. By making cancer monitoring as simple as wearing a patch, WHISPER could transform early diagnosis and personalized treatment, while also advancing Europe’s goals in precision medicine and digital health.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Net EU contribution
€ 260 347,92
Address
WELLINGTON SQUARE UNIVERSITY OFFICES
OX1 2JD Oxford
United Kingdom
Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data