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Predicting and implementing Out-of-equilibrium Waveform-controlled Electrochemical pRocesses

Project description

Harnessing time-asymmetric electrical waveforms for greener electrochemistry

The chemical industry is a significant contributor of industrial emissions, making its electrification a priority for Europe’s green transition. Using alternating electrochemical potentials to drive chemical reactions could improve sustainability. Research has lacked predictive methods and overlooked time-asymmetric waveforms despite chemical processes being asymmetric in time. With the support of the Marie Skłodowska-Curie Actions programme, the POWER project aims to use time-asymmetric potentials to achieve predictive control of electrosynthetic processes. It will use a systematic, theory-based experimental approach for designing asymmetric electrical waveforms that precisely control non-equilibrium electrochemical reactions. This approach could deliver a step change in yield and energy efficiency and open access to compounds with promising therapeutic applications.

Objective

The chemical industry is the third-largest source of global industrial emissions, calling for electrification strategies in line with the REPowerEU Plan. Using alternating electrochemical potentials (i.e. alternating current with square or sinusoidal waveforms) to manufacture chemical products is a promising route to more sustainable transformations. Yet current research relies mainly on trial-and-error and has so far focused on time-symmetric waveforms, even though redox processes are inherently time-asymmetric.

POWER will introduce a systematic, theory-driven experimental approach to harnessing alternating waveforms to drive chemical reactions under nonequilibrium conditions, opening efficient and sustainable pathways for chemical manufacturing. It pioneers the use of time-asymmetric potentials to achieve predictive control of electrosynthetic processes. By informing mechanistic models with targeted experiments, the project will establish a reproducible framework for theory-driven waveform design. Redox-induced nonequilibrium self-assembly of a molecular machine and annihilation electrochemiluminescence experiments will serve as strategic testbeds for model development and validation. The methodology will then be applied to the electrochemical synthesis of non-natural amino acids under alternating polarity. The objective is to demonstrate experimentally quantifiable gains in yield and energy efficiency, with up to an order-of-magnitude improvement over the state of the art, and to enable access to derivatives currently inaccessible with existing protocols, including precursors of peptides implicated in oncology and other therapeutic domains.

By advancing cleaner and more efficient electrochemical manufacturing powered directly by electricity, POWER will help reduce dependence on fossil fuels, cut CO2 emissions, and accelerate Europe’s transition to a sustainable economy.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

UNIVERSITE DE STRASBOURG
Net EU contribution
€ 242 260,56
Address
RUE BLAISE PASCAL 4
67081 Strasbourg
France
Region
Grand Est Alsace Bas-Rhin
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data