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Galen’s Antimicrobial Laboratory: Exploring the Science of Ancient Remedies against Infection.

Project description

Reconstructing Graeco-Roman antimicrobial pharmaceutics

The field of Graeco-Roman pharmacology remains an area of medical history where more research is needed, particularly regarding ancient drug formulas. This lack of research limits the full understanding of how medicinal substances were discovered and applied. Supported by the Marie Skłodowska-Curie Actions programme, the GALENA project examines the contribution of Galen of Pergamon (129-216 AD) in the field of medicine, focusing on antimicrobial therapies for eye and mouth infections, and combining philology, digital humanities, experimental archaeology, analytical chemistry and microbiological tests. The project aims to reproduce several drug formulas in the lab in order to determine their components and antimicrobial properties.

Objective

Graeco-Roman pharmaceutics remains a largely uncharted field in the history of medicine, particularly from a scientific perspective. The technical aspects of multi-ingredient formulations—how and why substances were selected, processed, and combined—are often overlooked. While modern scientists increasingly recognize the potential efficacy of ancient remedies, they rarely engage with the historical and theoretical dimensions of ancient pharmacology, and they lack access to the classical sources.
The GALENA project (Galen's Antimicrobial Laboratory: Exploring Natural Antiquities) addresses this gap by investigating pharmaceutical theory and practice in Galen of Pergamon (129–216 AD), the most influential physician of the Graeco-Roman world, who preserved extensive collections of recipes for remedies he considered most effective. Focusing on formulations for infection-related conditions affecting the eyes and oral cavity, the project combines philological analysis, digital humanities, experimental archaeology, analytical chemistry, and microbiological assays to reconstruct both the intellectual framework and the material outcomes of ancient drug-making.
The study will (1) situate Galen’s treatments within his pathology of infection-related diseases; (2) identify recurring patterns in ingredient selection, processing, and combination; and (3) replicate formulations in the laboratory to analyse their chemical composition and assess potential antimicrobial effects.
By integrating humanities and laboratory sciences, GALENA will pioneer a genuinely interdisciplinary methodology. The project will enrich the history of medicine, advance our understanding of Graeco-Roman pharmacology, and foster collaboration across disciplines. It will also contribute to the fellow’s career development through a tailored training programme and may provide scientific leads in the search for novel approaches to combat antimicrobial resistance.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Net EU contribution
€ 193 643,28
Address
VIA ZAMBONI 33
40126 Bologna
Italy
Region
Nord-Est Emilia-Romagna Bologna
Activity type
Higher or Secondary Education Establishments
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Total cost
No data

Partners (1)