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Deciphering Micro- and Nanoplastic-Mediated Biotransformation and Biodistribution of Heavy Metals in Fish

Project description

Microplastics as heavy metal vectors in aquatic ecosystems

The tiniest shreds of plastic are the most dangerous. Micro- and nano plastics can enter aquatic systems with significant implications for both ecological and human health. Supported by the Marie Skłodowska-Curie Actions programme, the METAPlastic project explores interaction of the micro-and nano-plastics with toxic metals such as arsenic, mercury and chromium in aquatic settings. It also investigates how that influences their bioaccumulation in fish. More specifically, the study will use multiple methods including zebrafish assays, cutting-edge chemical microscopy/analysis and predictive models through artificial intelligence technology to understand the impacts of plastic properties on metal accumulation and health implications.

Objective

Micro- and nanoplastics (MNPs) are pervasive in aquatic ecosystems and pose growing ecological and human health risks by acting as vectors for toxic heavy metals (HMs) such as arsenic, mercury, and chromium. Their high surface area and surface reactivity enable strong HM adsorption, altering bioavailability and toxicity once ingested by fish, which are key links in the human food chain. Yet, it remains unclear how fundamental MNP traits including size, polymer type, and environmental aging, govern HM bioaccumulation, in vivo biotransformation, and organ-specific toxicity.
The METAPlastic project will address these gaps by combining zebrafish exposure studies with state-of-the-art analytical techniques (e.g. HPLC/GC-ICP-MS and synchrotron-based XAFS for speciation; laser-ablation ICP-MS and synchrotron micro-XRF for spatial mapping) and advanced machine learning models. This integrated approach will provide mechanistic insights into how MNP properties dictate HM fate and toxicity and establish predictive tools for risk assessment under complex environmental scenarios.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2025-PF

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Coordinator

THE UNIVERSITY OF BIRMINGHAM
Net EU contribution
€ 276 187,92
Address
Edgbaston
B15 2TT Birmingham
United Kingdom
Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Links
Total cost
No data

Partners (1)