Project description
Multifunctional nanogel-based therapy development for DIPG
One of the rarest brain tumours, diffuse intrinsic pontine glioma (DIPG) is the main reason for brain tumour-related deaths among children. Although the treatment can be considered quite aggressive, it is difficult mainly due to insufficient drug delivery and fast progression of the condition. Supported by the Marie Skłodowska-Curie Actions programme, the psDIPG-NG project will focus on developing a multimodal nanogel. With the use of advanced microfluidics and organ-on-a-chip technologies, it will mimic human physiology and test potential therapies without conducting unnecessary experiments with animals. Ultimately, the project could pave the way for improved clinical prospects and advance next-generation nanomedicine approaches.
Objective
Diffuse intrinsic pontine glioma is a highly invasive pediatric brain cancer with frequent recurrence and progression of surgical wound tissues after surgical resection. To address these challenges, the fellow will develop a novel multifunctional nanogel that enhances drug delivery and efficacy. This innovative strategy has the potential to improve treatment outcomes for children suffering from DIPG by addressing biological barriers and complexity of tumor microenvironments. The project will apply a microfluidic device and organ-on-a-chip model to mimic normal physiological tissue and replace animal experiments. The fellow will bring his experience on the synthesis, characterization, and biological evaluation of nanogel gained during his PhD and postdoctoral studies to the host lab of Dr Katerina at UP, an expert in nanomedicine. The proposed study will be of significant fundamental and practical importance in childhood brain cancer, as it offers novel nanogel formulations with potential applications for even other types of brain malignancies. Comprehensive training in the host lab and international research visits will broaden the fellow's experimental skills and transfer his new skills and knowledge to the local researchers and technicians. The study findings will be disseminated through three publications and presented orally and as a poster at the international conferences and local research events. The project is highly interdisciplinary, involving Bioengineers, chemists, and pediatric oncologists. It also aligns with the European objectives of sustainable growth and climate change mitigation. The supervisors, Dr Kateřina Poláková and Prof. Professor Andreas Hierlemann (ETH Zurich), have the experience and resources to effectively supervise the fellow and ensure the implementation of MSCA action. Through skill development and extensive training, the fellow will be well-positioned for significant career advancement and a future leadership role.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology nanomedicine
- medical and health sciences clinical medicine oncology
- engineering and technology other engineering and technologies microtechnology organ on a chip
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
771 47 Olomouc
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.