Project description
Gut bacteria and diabetes development
Emerging evidence indicates that the gut microbiome plays a key role in the development of type 2 diabetes. However, most studies have identified associations rather than causal relationships, and it remains unclear which specific bacterial strains drive metabolic dysfunction rather than simply accompanying it. With the support of the Marie Skłodowska-Curie Actions programme, the STRIKE-T2D project proposes to carry out faecal microbiota transplantation from pre-diabetic donors into germ-free mice to establish causal links between specific gut bacterial strains and glucose metabolism. Combining high-resolution metagenomics, multi-omics analysis and causal modelling, researchers will identify microbial strains that reproducibly alter host metabolism, pointing towards new diagnostic and therapeutic strategies for type 2 diabetes.
Objective
STRIKE-T2D (Strain-level Interpretation of Key Effectors in Type 2 Diabetes) aims to uncover specific gut microbial strains that causally influence the progression of type 2 diabetes (T2D). While many human studies have linked microbiome changes to metabolic disease, most remain observational and lack the resolution to identify microbial drivers rather than bystanders.
This project integrates a longitudinal, genetically controlled fecal microbiota transplantation (FMT) mouse model with strain-resolved metagenomics and multi-omics analysis. Using prediabetic donors from a well-characterized cohort (IGT), germ-free mice will be colonized and phenotyped over time to track microbiota-driven metabolic changes. High-resolution metagenomic workflows will enable reconstruction and tracking of microbial strains and genetic variants linked to host glycemic outcomes.
Beyond association, STRIKE-T2D will apply causal mediation models to link microbial features with intermediate metabolic traits, and experimentally validate prioritized candidates both in vivo and in vitro. Ultimately, the project will identify microbial strains and functions that reproducibly alter host glucose metabolism—offering new insights into disease pathogenesis and pointing toward future diagnostic or therapeutic strategies.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine endocrinology diabetes
- medical and health sciences clinical medicine transplantation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
405 30 Goeteborg
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.