Objective
Chemical safety assessment is moving away from animal testing, but the regulatory uptake of non-animal methods (NAMs) is slowed by the lack of frameworks that connect mechanistic data to decision-making. COMPASS responds to this challenge by establishing a comprehensive, data-driven framework that connects mechanistic evidence from NAMs with Adverse Outcome Pathways (AOPs), creating a foundation for predictive, human-relevant, and cross-species safety assessment. A central aim is to enable the transparent selection of the most informative test systems and the design of minimal yet high-impact testing strategies, ensuring that complex biological mechanisms are captured. By addressing urgent regulatory needs such as lung fibrosis, highlighted in the OECD pulmonary fibrosis AOP and increasingly linked to nanomaterial exposures, the project will demonstrate how mechanistic insight can be harnessed for endpoints where current assessment tools are insufficient. Beyond this targeted case, COMPASS generalises the approach to systemic toxicity, enabling streamlined first-tier strategies that capture a broad range of mechanisms and support Safe-and-Sustainable-by-Design innovation. In doing so, the project strengthens the scientific basis of regulatory decision-making, accelerates the transition away from animal testing, and contributes to the European Green Deal’s ambition of a toxic-free environment and a globally competitive, sustainable chemical sector.
Fields of science (EuroSciVoc)
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
33100 Tampere
Finland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.