Objective
Protein biologics hold immense therapeutic promise, yet their clinical potential is constrained by a fundamental barrier: the cellular membrane. While several protein-based drugs have achieved clinical success, they remain limited to extracellular targets. Unlocking intracellular access would dramatically expand the therapeutic scope of protein drugs, enabling intervention at previously inaccessible disease sites.
Current intracellular delivery strategies rely on physical or amphiphilic mechanisms, both of which suffer from critical drawbacks including cytotoxicity, cargo aggregation, and endosomal entrapment. PINCLUS proposes a transformative alternative by leveraging super-chaotropic boron clusters as transmembrane carriers. These inorganic, doubly anionic, water-soluble clusters bypass endosomal pathways and avoid aggregation or membrane disruption, offering a biocompatible route for intracellular transport.
Building on pioneering work in chaotropic delivery, PINCLUS introduces a novel strategy using boron clusters as protein nanocarriers to enable precise modification across diverse protein types and ensures traceless release of the native protein upon internalization, preserving biological function.
Through interdisciplinary training in chemistry, biology, and biophysics, and supported by the host’s expertise in chaotropic transporters, this action will establish the first proof-of-concept for selective intracellular delivery of chaotropic protein hybrids. PINCLUS will unlock new frontiers in protein drug development and empower the applicant’s transition to scientific independence.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biophysics
- natural sciences chemical sciences inorganic chemistry metalloids
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
15782 Santiago De Compostela
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.