Objective
The cerebral cortex depends on a precise balance of excitatory pyramidal cells (PCs) and inhibitory interneurons (INs), but how IN distributions specific to different areas develop remains unknown. Contrary to the idea that programmed cell death shapes these patterns after birth, preliminary data suggest that INs are heterogeneously deployed before programmed cell death through yet-to-be-identified molecular cues. The IN-PATTERNS project proposes that a global molecular code, mainly driven by signals from PCs, guides different IN allocations across cortical areas. To test this hypothesis, this project combines (i) single-cell RNA sequencing and bioinformatic ligand–receptor analyses to build a comprehensive PC–IN interactome when interneurons stop migrating; (ii) high-resolution spatial transcriptomics to map candidate gene expression; and (iii) in utero electroporation to causally validate PC cues. This interdisciplinary approach will provide public datasets, molecular atlases, and open-source analysis tools, forming a basis for understanding cortical circuit assembly and its disruption in disease. With the expertise of the Marin lab in interneuron biology and genomics, along with dedicated support from the Centre's bioinformatics team and my experience in mouse embryology, IN-PATTERNS is ambitious but feasible, with the potential to significantly advance my training and establish new paradigms in developmental neuroscience.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences clinical medicine embryology
- natural sciences chemical sciences electrochemistry bioelectrochemistry electroporation
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC2R 2LS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.