Objective
Prostate cancer (PCa) is a leading cancer in men, with approximately one in eight diagnosed during their lifetime. Early detection through lateral flow immunoassays (LFIAs) is critical for improving survival rates globally. However, the widely used prostate-specific antigen (PSA) biomarker suffers from limited specificity, as elevated PSA levels are also observed in non-cancerous conditions such as benign prostatic hyperplasia. Recent studies indicate that distinct PSA proteoforms, protein variants resulting from different glycosylation modifications, are linked to specific prostate diseases. Despite this, PSA proteoform-based diagnostics remain underdeveloped due to an incomplete understanding of PSA at the proteome level and detection challenges in false positive and negative. PRIME aims to overcome these barriers by enabling accurate identification of PSA proteoforms without the use of harsh chemicals that could degrade glycosylation patterns. It also seeks to develop a proteoform-resolved LFIA for reliable, ease-to-use and point-of-care PCa diagnosis by integrating antibody mimics and a time-delayed pad into the LFIA platform. The success of PRIME is supported by my expertise in antibody mimic nanoparticle design and mass spectrometry-based proteomics, the world-leading biosensing and LFIA expertise of my host group led by Prof. Dame Molly Stevens at the University of Oxford, and clinical collaboration with Prof. Freddie Hamdy CBE, who provides access to blood samples from the largest randomized controlled study of PCa in the United Kingdom.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- engineering and technology environmental biotechnology biosensing
- medical and health sciences clinical medicine oncology
- engineering and technology nanotechnology nano-materials
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.