Objective
The heart-brain axis (HBA) is a critically important bidirectional communication network that is essential for maintaining physiological equilibrium. Its dysregulation is a key pathological mechanism in disorders such as stroke, where an injury in one organ can precipitate secondary failure in the other, drastically worsening patient outcomes. A major obstacle is the technological gap that prevents from simultaneously imaging the heart and brain as an interconnected system; capturing their interactions at the microscopic scale where early microvascular pathophysiology begins. To address these, SAMUL (Simultaneous Acquisition of Microvascular and functional ULtrasound), aims to overcome this limitation by developing the integrated, non-invasive ultrasound technique for synchronized dual-organ assessment. The project will synchronize two research ultrasound scanners to acquire ultrafast data simultaneously from the heart and brain in rodents. It will interleave contrast-enhanced modes for super-resolution Ultrasound Localization Microscopy (ULM) with non-contrast functional Ultrasound (fUS) imaging (WP1). A unified computational pipeline will then be developed to generate co-registered, quantitative maps of microvascular architecture and organ function (WP2). This integrated platform will be rigorously validated in a longitudinal rodent model of ischemic stroke (WP3). The goal is to perform the first quantitative correlation analysis of neuro-cardiac coupling, linking imaging-derived parameters to early physiological symptoms to identify predictive biomarkers of HBA dysregulation. By providing a validated, open-source toolset, SAMUL will establish a new standard for multi-organ physiological investigation. This work is a critical first step that paves the way for future diagnostic applications, with the potential to transform patient care in neuro-ICUs and stroke units from a reactive to a proactive model through enabled early intervention.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.