Objective
Apple scab, caused by the fungus Venturia inaequalis, is the most damaging disease of apple (Malus domestica), capable of destroying up to 70% of yields in susceptible orchards and driving a heavy fungicide regime. Domestication and the genetic uniformity of modern orchards have originated the development of highly virulent pathogen strains that now threaten not only cultivated apples but also wild relatives such as Malus sieversii, a vital reservoir of genetic diversity.
Like many plant pathogens, V. inaequalis relies on secreted effector proteins to suppress host immunity and promote infection. Among these, the FOLD-like effector SSPK has emerged as a key factor in adaptation to domesticated apples, showing distinct allelic variation between agricultural and wild host populations. Despite its apparent importance, the molecular function, host targets, and evolutionary trajectory of SSPK remain unknown.
VinaFOLD will combine comparative genomics, functional assays, and structural modeling to (i) trace the evolution and diversification of SSPK, (ii) dissect its localization, activity, and role in virulence in planta, and (iii) identify its host targets or immune receptors in wild and domesticated Malus. Beyond elucidating a model of domestication-driven pathogen adaptation, this work will deliver knowledge for breeding durable resistance, reducing chemical inputs, and preserving biodiversity in line with EU sustainability goals.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences biological sciences microbiology mycology
- natural sciences biological sciences ecology ecosystems
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
49035 Angers Cedex 01
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.