Objective
GlycoAxis aims to train 13 Doctoral Candidates (DCs) to address a major blind spot in brain-health research: the molecular mediators linking gut microbiota to neuroinflammation. Across over 600 brain diseases, immune-inflammatory pathways and gut microbial imbalances co-occur, giving rise to the concept of a gut-immune-brain axis (GIBA). Yet current studies remain largely correlative and fail to identify the molecular effectors of this dialogue. GlycoAxis places Gram-negative surface glycans, lipopolysaccharides and capsular polysaccharides, as central molecular keys to decode the GIBA. These surface-exposed and structurally diverse molecules drive immune sensing, cross biological barriers, and can be chemically tagged, imaged and profiled, making them ideal candidates for functional and translational exploration.
Only a coordinated effort combining chemistry, structural biology, microbiology, immunology, and neurobiology can tackle the complexity of GIBA and translate discoveries into innovation. GlycoAxis integrates these disciplines into a multisectoral and interdisciplinary network to train DCs while delivering tangible scientific and technological outputs. Through its multidimensional approach, it will (i) establish the molecular framework of gut bacterial glycans relevant to the brain; (ii) integrate advanced (neuro)immunological models to clarify how glycans are sensed by host receptors and modulate neuroinflammation; (iii) produce translational platforms for glycan profiling, imaging and biomarker discovery, paving the way for innovative diagnostics in brain health. Each DC will pursue an individual research project bridging fundamental and translational science, enriched by secondments with industrial partners.
By moving the field from correlation to causation, GlycoAxis will strengthen Europe leadership at the chemistry-neuroscience interface and equip a new generation of scientists with cutting-edge skills for careers in academia and industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine immunology
- natural sciences biological sciences biochemistry biomolecules carbohydrates
- natural sciences biological sciences microbiology
- natural sciences biological sciences molecular biology structural biology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
80138 Napoli
Italy
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Participants (10)
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48149 Muenster
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28006 Madrid
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M13 9PL Manchester
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00014 Helsinki
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4365 ESCH-SUR-ALZETTE
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3012 Bern
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80539 Planegg
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20157 MILANO
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5000 Namur
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14476 POTSDAM
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Partners (5)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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80125 NAPOLI
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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5032 GEMBLOUX
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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53100 SIENA
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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28040 Madrid
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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14195 Berlin
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