Objective
Ticks are competent vectors of several viruses, bacteria, and parasites, that threaten the health of humans and animals worldwide and highlight the importance of tick biology research. Although these systems are involved in almost all biological mechanisms of tick life, the signalling networks of tick neurotransmitters and neuropeptides remain a highly neglected topic in tick studies. In the case of serotonin (5-HT) and its receptors (5-HT-R), there is evidence for the presence of a dual serotonergic system that involves the reception of exogenous and endogenous 5-HT. However, the regulatory network of 5-HT remains largely unexplored, therefore the SeroTick project aims to provide a comprehensive investigation of serotonergic signalling and serotonin receptors in Ixodes ricinus ticks. We will utilize immunohistochemistry and immunogold TEM to explore the complexity of serotonergic neurons and 5-HT-Rs in the synganglion, salivary glands and midgut; perform receptor expression assays to determine the functional and pharmacological identity of serotonin receptors; and employ the RNA interference technique of gene silencing to assess the role of 5-HT-Rs in the physiology of salivary glands and migdut. The proposed project integrates molecular biology, neurophysiology, pharmacology, proteomics, and advanced imaging to dissect serotonergic signalling in Ixodes ricinus. The SeroTick project aims to significantly expand the currently limited knowledge about tick signalling networks and lay the foundations for innovative tick control strategies. Our central objective is to generate tools that disrupt tick feeding by targeting life-essential serotonergic processes, and this will be achieved through rigorous fundamental research. Such advances have the potential for considerable scientific, medical, veterinary, and economic impact.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences microbiology virology
- medical and health sciences basic medicine physiology
- medical and health sciences basic medicine pharmacology and pharmacy
- natural sciences biological sciences molecular biology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-PF
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75007 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.