Objective
The lungs play a crucial role in breathing and exchanging gases, and are vulnerable to numerous illnesses, including cystic fibrosis, cancer, asthma, and infections. The application of gene-based therapies is a crucial focus in the development of new treatments for these life-threatening conditions. The administration method is crucial for lung targeted genetic therapies: Inhalation stands out as a non-invasive route, providing ease of use, quick action, localized treatment, and fewer side effects compared to intravenous methods. However, despite its advantages, inhaled RNA therapies have yet to gain clinical approval due to challenges in navigating the complex lung environment and ensuring effective gene delivery.
In LUNG-GENEMED, we aim to develop advanced delivery systems that effectively penetrate lung barriers—such as mucus, surfactant proteins, and mucociliary clearance—to enhance treatment efficacy while minimizing dosage. We will build up a multidisciplinary network of 11 academic partners and 8 non-academic associated partners with expertise in soft matter, drug delivery, aerosolization, respiratory physiology and physiopathology and organ-on-chip technology. We will recruit and train 13 Doctoral Candidates (DC) for generating highly skilled scientists with competencies at the cutting edge of gene therapy who will spread their acquired knowledge across Europe well beyond the timeframe of this project. The training program will focus on developing tailored genetic nanotherapeutics for lung delivery to target untreatable diseases by elucidating the intricate bio-nano interaction patterns within the lungs. Organ-on-chip models of lungs will be used to test safety and efficacy of therapeutics, while reducing animal testing. Overall, we will tackle the current barriers arresting gene therapy by training the next generation scientists through individual training-through-research projects and secondments, scheduled in both academic and non-academic partners.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20133 Milano
Italy
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Participants (10)
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75794 Paris
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
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28040 Madrid
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
50121 Florence
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
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69117 Heidelberg
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10117 Berlin
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20009 San Sebastian
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28041 Madrid
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
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85764 Neuherberg
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B15 2TT Birmingham
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Partners (11)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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20126 MILANO
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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W12 7RZ London
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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SN2 1FL SWINDON
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
34570 Montarnaud
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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223 70 Lund
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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3600 Frederikssund
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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11500 El Puerto De Santa María
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
31400 Toulouse
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
48940 Leioa
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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80539 Planegg
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
151 85 Sodertaelje
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.