Objective
Decoding how the “non-coding” genome controls gene expression is one of the grand challenges of modern biomedicine. Most disease-associated variants fall in regulatory DNA, yet their effects on gene regulation remain largely unpredictable, limiting diagnosis, risk stratification and the design of safe gene and cell therapies. cisCODE is an MSCA Doctoral Network that will train 15 Doctoral Candidates to crack the cis-regulatory code by combining cutting-edge genomics with artificial intelligence and synthetic biology.
The network gathers 13 academic partners, completed with 9 non-academic partners across experimental and computational disciplines. Together, they will (i) decode the sequence “grammar” and modular function of cis-regulatory elements, (ii) map the rules of communication and compatibility between distal enhancers and promoters in three-dimensional chromatin, and (iii) build causal, predictive enhancer-based gene regulatory networks in health, stress, inflammation and cancer. Doctoral projects will leverage single-cell multi-omics, high-throughput functional assays, advanced 3D genome profiling and next-generation AI models to move from descriptive catalogues to mechanistic and predictive understanding.
cisCODE is also a training engine for Europe. A structured, international and intersectoral programme will provide Doctoral Candidates with personalised research and career development plans, network-wide schools, secondments in industry and clinics, and dedicated training in open science, data stewardship, ethics and innovation.
By delivering new models, datasets and synthetic regulatory tools openly to the community, cisCODE will accelerate interpretation of regulatory variants, support the rational design of precision therapies, and consolidate Europe’s leadership at the interface of regulatory genomics, artificial intelligence and personalised medicine.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences synthetic biology
- medical and health sciences clinical medicine oncology
- medical and health sciences health sciences personalized medicine
- medical and health sciences medical biotechnology cells technologies
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2025-DN-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75654 Paris
France
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Participants (13)
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1165 KOBENHAVN
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
9052 ZWIJNAARDE - GENT
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02-093 WARSZAWA
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08003 Barcelona
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1010 Wien
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28006 Madrid
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20121 Milano
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5230 Odense M
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00-661 Warszawa
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SW7 2AZ London
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4051 Basel
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1015 Lausanne
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142 20 Praha 4
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Partners (13)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1098 XH Amsterdam
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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1304 COSSONAY
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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CB4 0DS Cambridge
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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14165 Berlin
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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13009 Marseille
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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13014 Nimes
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1018 AK Amsterdam
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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13284 Marseille
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
39005 SANTANDER
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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116 36 Praha 1
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08002 Barcelona
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3000 Leuven
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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20122 Milano
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.