Objetivo The objectives of the project are to provide knowledge for the prevention of waste dust related disease through: * Coordination and optimization of ongoing research projects, * Identification of causative agent(s) and pathological reactions caused by these, development of a measurement strategy, * Evaluation of the no reaction threshold, based on dose response relationships, for establishment of guidelines, * Develop improved diagnostic criteria for disease caused by waste handling and, * Develop information material to disseminate knowledge for preventive programmesInitially, a review of information on waste dust exposure and disease will be made. This material, which is going to be continuously updated, will be available for outside use. The scientific data base will be analyzed and a state of the art article for publication in a scientific journal will be prepared. Investigations will be made of exposure conditions in waste processing facilities with different technical characteristics and with particular reference to airborne dust, bacterial endotoxin and (1->3)-B-D-glucan - a cell wall component of moulds. The importance of source characteristics, storage and waste collection for the worker exposure will be studied. Workers engaged in different parts of the waste handling industry will be examined with particular reference to the presence of airways inflammation and asthma. Persons will be challenged with bacterial endotoxin and extracts of waste dust to study the development of inflammation and obtain a basis for a no reaction threshold. In these experiments, new effect and endpoints in terms of inflammatory markers and cell reactivity will be evaluated. Animal experiments will be made to study the mechanisms behind the diseases present among waste workers with particular reference of bacterial endotoxin and (1 ->3)-B-D-glucan from mould cell walls. Information material for researchers, workers and management will be prepared. Ámbito científico medical and health sciencesclinical medicinepneumologyasthmaengineering and technologyenvironmental engineeringwaste managementnatural sciencesbiological sciencesmicrobiologybacteriology Programa(s) FP4-BIOMED 2 - Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998 Tema(s) 4.5.8 - Risk factors of occupational and environmental diseases Convocatoria de propuestas Data not available Régimen de financiación CSC - Cost-sharing contracts Coordinador GOETEBORG UNIVERSITY Aportación de la UE Sin datos Dirección 16,Medicinaregatan 16 405 30 GOETEBORG Suecia Ver en el mapa Coste total Sin datos Participantes (8) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo Institut Pasteur Francia Aportación de la UE Sin datos Dirección 25,Rue du Docteur Roux 75724 Paris Ver en el mapa Coste total Sin datos Institut de Recherche Appliquée en Allergologie et Immunologie Clinique Suiza Aportación de la UE Sin datos Dirección 15,Rue Lombard 1205 Genève Ver en el mapa Coste total Sin datos Landbouwuniversiteit Wageningen Países Bajos Aportación de la UE Sin datos Dirección 6700 AE Wageningen Ver en el mapa Coste total Sin datos UNIVERSITY OF AARHUS Dinamarca Aportación de la UE Sin datos Dirección 180,Vennelyst Boulevard, 6 8000 AARHUS C Ver en el mapa Coste total Sin datos Universidade Nova de Lisboa Aportación de la UE Sin datos Dirección Ver en el mapa Coste total Sin datos University of Luton Reino Unido Aportación de la UE Sin datos Dirección Park Square LU1 3JU Luton Ver en el mapa Coste total Sin datos Università degli Studi di Ferrara Italia Aportación de la UE Sin datos Dirección Via Fossato di Mortara 23 44100 Ferrara Ver en el mapa Coste total Sin datos Université Libre de Bruxelles Bélgica Aportación de la UE Sin datos Dirección 322,Rue Haute 1000 Bruxelles Ver en el mapa Coste total Sin datos
