Objective
Disproportionate collagen deposition in the heart impairs cardiac function and may contribute significantly to the poor prognosis of cardiac hypertrophy. Although there has been considerable work elucidating humoral factors which promote myocardial fibrosis much less is known about antifibrotic mechanisms. We propose that atrial and brain natriuretic peptide (ANP and BNP) and nitric oxide (NO) antagonise the effects of fibrotic factors in the myocardium. To address this hypothesis we will: (i) establish the natriuretic peptide receptor subtypes expressed by cardiac fibroblasts; (ii) compare changes in the expression of these subtypes and nitric oxide synthase in cardiac tissue from animal models of cardiac hypertrophy with and without myocardial fibrosis; (iii) examine the effect of ANP, BNP and NO donors on cardiac fibroblast proliferation and collagen synthesis 'in vitro'; and (iv) investigate the effect of a combined neutral- endopeptidase/angiotensin-converting enzyme inhibitor on collagen deposition in the heart 'in vivo'. These studies will provide valuable insight into the role of ANP, BNP and NO in regulating cardiac remodelling and their potential therapeutic value in the treatment of cardiac hypertrophy.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
W12 0NN London
United Kingdom
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