Objective
Of the 50 or more structurally distinct phospholipids present in platelets only a few have been quantitatively analysed or shown to participate in cell signalling or other platelet functions. Many lipids can now be analysed by GC-MS and LC-MS and one and 2D-NMR lipid (and cytosolic) profiles have been analysed for all classes of phospholipids. These two complementary approaches will be utilised to elucidate the role of specific lipids and lipid moieties in cell signalling and in the morphological changes induced by agonists and antagonists like collagen, thrombin, PAF, NO etc. Comparison of the profiles from resting and stimulated platelets, when carried out in a time-and-dose-dependent manner, should correlate with shape change, aggregation, exocytosis-degranulation, PAF and eicosanoid formation by different phospholipases A2, C and D. Comparison of the platelet lipid profiles from healthy and diseased volunteers will be used to correlate changes in specific with the severity of platelet associated diseases such as thrombosis, hyperlipidemias, etc.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences biochemistry biomolecules lipids
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1N 1AX LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.