Objective
The chromosomal region constituting the major histocompatibility comple (Mhc) has undergone complex evolution which is often difficult to decipher. An important aid in the elucidation of the Mhc evolution is the presence of Alu elements (repeats) which serve as markers for tracing chromosomal rearrangements. As the first step toward the stablishment of sets of evolutionary markers for the Mhc, Alu elements present in selected Mhc haplotypes of different prosimians species will be identified.
Restriction fragments of lambda phage clones from the libraries of thos mentioned species will be hybridized with Alu-specific probes, Alu elements will be amplified by the polymerase chain reaction (PCR), and the amplification products subsequently sequenced. Assignments of the Alu elements obtained to the different specific-families will be done and then, putative duplication times of the different DRB genes stablished. Finally, comparison of Alu content in prosimians and primates will help to decipher the evolutionary mechanisms driving the actual composition and differential localisation of the Mhc-DRB genes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences zoology mammalogy primatology
- natural sciences biological sciences microbiology virology
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
72076 Tübingen
Germany
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