Objective
The aggregation process of amphiphilic molecules, such as surfactants a lipids, into micelles, bilayers, vesicles and biological membranes, and the interaction between them, is involved in the most common cellular activity. One of the major challenges is to understand the structural aspects that lead to the formation of the most favoured structure under molecular geometry and packing constraints considerations that minimizes the interfacial energy per molecule. Particularly, the curvature of the vesicles, or lipid bilayers, can be regulated by altering the ratio of the different lipid types that can pack together. Therefore, when protein molecules are incorporated into these structures often result in a preferential clustering of specific lipids around a protein.
Our purpose is to study the effects of membrane proteins on the curvatu of bilayer membranes. In particular, we will consider two cases:
(1) Does a bilayer membrane change its local curvature at the particular site, where a single protein is inserted into the membrane?. How is the geometry of the protein related to a successful local bending of a membrane?. What are the relevant forces for this process?
(2) What are the relevant forces leading to aggregation of proteins and the subsequent induced curvature of the bilayer?. Is aggregation driven by the development of curvature?. How does the process of a protein-induced curvature of a bilayer differ from that of a monolayer ?
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences biochemistry biomolecules lipids
- natural sciences mathematics pure mathematics geometry
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
52428 Jülich
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.