Objective
The objective of this project is to study the role of GTPases of the Rho subfamily during phagocytosis in macrophages Interaction of microorganisms with cell surface receptors initiates signalling pathways, leading to submembraneous actin assembly and ingestion of the particle. Rho, Rac and Cdc42 are involved in the control of various cellular processes dependent on actin polymerization. First, We shall analyse the effect of inactivating these proteins on phagocytosis of IgG-coated particles. Next, using transfection and microinjection techniques we shall define how Rho, Rac and Cdc42 control signalling pathways linking ligation of Fc*R or CR3 to actin polymerization during phagocytosis in COS cells and U937 derived macrophages. Finally, we shall analyse the molecular pathways activated upon interaction between macrophages and different bacterial pathogens. These studies may allow us to identify intracellular targets for virulence factors of Yersinia spp. for example, which are able to impair actin polymerization and inhibit their uptake.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences microbiology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 6BT LONDON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.