Objective
The phosphorylation of tyrosine residues is an essential element of many signal transduction pathways triggered by hormones, mitogens, and oncogenes that lead to processes such as cell growth, proliferation, and differentiation. Protein phosphorylation is reversible and controlled by the opposing action of protein kinases and phosphatases that catalyze phosphorylation and dephosphorylation, respectively. In our work, we will investigate the crystal structure of a representative member of the receptor-like protein tyrosine phosphatase, namely, human PTPu, using X-ray diffraction techniques. This is particular interisting in light of the observation that the extracellular portion of PTPu, which is reminiscent of the extracellular portion of neural cell adhesion molecules (N-CAMs), participates in forming homophilic binding interactions. It is possible that signals resulting from cell-cell contacts may be transduced across the plasma membrane resulting in modulation of the catalytic activity of PTPu. It is of interest to understand the structure of PTPu which would provide insight into the structural mechanism of transmembrane signal transduction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 3QU Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.