Objective
Pyruvate dehydrogenase (PDH) is a key control point in eukaryotic carbo metabolism and thus highly regulated. Plant cells have two forms of PDH one in the mitochondrion and one in the the chloroplast. The object of my proposed study is to determine the regulation of mitochondrial PDH in vivo. This will be performed using antisense technology in transgenic potato plants transformed with the E1a subunit, pyruvate decarboxylase. Transgenic plants with altered amount of E1a protein will be studied. Transgenic mitochondria will then be compared to wildtype mitochondria in respect of oxygen uptake, citric acid flux and the PDH activation state of the enzyme in vivo. I will use the transgenic plants to determine the flux-control coefficient of this step on the respiratory flux and thus determine the importance of PDH in regulating respiration in vivo Such studies are of fundamental importance towards an understanding of how crop yield can be improved by biotechnology.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries agriculture
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
OX1 3RB OXFORD
United Kingdom
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