Objective
A neurophysiological investigation will be carried out on the mechanisms of the induction of long-term depression (LTD) and depotentiation (DP) of glutamatergic excitatory synaptic transmission in the rat hippocampus. The research will concentrate on investigating the role of Ca in the induction of LTD/DP, including the role of the influx of Ca via NMDA receptors and voltage-gated Ca stores in releasing Ca or acting as a sink for Ca during the induction of LTD/DP. The stores that will be mainly investigated are those of the endoplasmic reticulum, and in particular, those which are ryanodine-sensitive and inositol 1,4,5-triphosphate-sensitive. The role of each store will be investigated by measuring the induction of LTD/DP in the presence of selective agents which bind to ryanodine or IP3 receptors and either induce or block release of Ca from the stores.
Fields of science (EuroSciVoc)
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
2 Dublin
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.