Objective
Combinatorial chemistry has developed as a novel approach to lead generation for new biological targets uncovered by advances in molecular biology. Libraries of small peptides have been prepared but the large number of conformations that are available to small unconstrained peptides limits the potencies of the "hits" that are found. It is proposed to design and prepare conformationally restricted amino acids for incorporation into libraries of small peptides. Any "hits" from such libraries may be expected to have higher potencies as compared to the "hits" from unconstrained libraries. There are two aspects to the research - firstly we need a system of confirmational analysis to aid the design of a range of analogues covering different areas of conformational space. The other aspect is the actual synthesis of specific conformationally restrained amino acids. The project will involve computational chemistry and synthetic chemistry within a medicinal chemistry setting, and provide a good training for either academia or industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine medicinal chemistry
- natural sciences biological sciences biochemistry biomolecules
- natural sciences chemical sciences organic chemistry amines
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
TW8 9EP Brentford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.