Objective
In all eukaryotes the centromeres are essential for separation of chromosomes into dividing cells. The centromere DNA forms together with several proteins a large complex called the kinetochore. The role of the kinetochore is to mediate contacts with the microtubules and motor proteins that pull the chromosomes to opposite poles of the mitotic and meiotic spindles. The centromere DNA sequence has been defined in fission yeast but the protein components are hitherto unknown. The aim of this project is to clone and characterise the genes which encode trans-acting components of the fission yeast kinetochore. To this end six temperature sensitive lethal mutations called cspl -6 (centromeric suppressors of position effects) and six nonlethal mutations (csp7-12) have been isolated. These are good candidates for kinetochore mutations because they affect the in vivo accessibility of the centromere DNA and cause chromosome loss.The corresponding genes will be cloned and sequenced. The immunolocalisation of the gene-products will be investigated.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences genetics chromosomes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EH4 2XU EDINBURGH
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.