Objective
Fas is a member of the TNF receptor family of proteins, that, when cross-linked by mAbs or its physiological ligand (FasL), induces apoptosis. Fas-mediated apoptosis is of physiological relevance in the regulation and function of the immune system. A biochemical mechanism for Fas-induced apoptosis, as well as for the apoptosis process itself, is unknown . Oxidative damage has been implicated in some forms of TNFmediated cytotoxicity. Mitochondrial respiration is the cellular process from which free radical could be more easily generated, and it is directly implicated in TNF-induced cell death of L929 cells. The implication of mitochondrial function in Fas-based cytotoxicity will be tested using mitochondrial DNA-depleted U937 and Jurkat cells, as both the promonocytic U937 and the T cell line Jurkat are sensitive to Fas-induced cytotoxicity. Fas-based cytotoxicity will be tested using effector T cells, that express the functional FasL on their surface upon activation, especially CD8+ CTL clones.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine immunology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
50013 Zaragoza
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.