Objective
The processes of cellular proliferation are regulated through the activation of specific signal trasduction pathways resulting in alterations of the gene expression pattern. Thus, the ultimate targets of these pathways are represented by nuclear factors which bind to specific enhancer sequences and integrate information from promoter sequences and different extra- and intracellular signals at the level of transcriptional control. Among these factors, several proto-oncogenes have been described. Altered regulation of proto-oncogenes may lead to unrestrained cellular growth, wich is a remarkable feature of the transformed phenotype. Several data indicate that CREM proteins, nuclear factlors belonging to the leucine zipper proteins family, are able to regulate the expression of some oncogenes, i. e. jun and fos, both at transcription and post-translational levels. In this perspective, the overall aim of this project is to investigate the possibility that CREM proteins might modulate cell proliferation by affecting the activity of immediate-early response proto-oncogenes. In order to adress this question, several experiments will be performed both in cultured cells, by the use of transformation assays, and in the whole organism, by the establishment of transegenic mouse lines, to assess whether CREM proteins might affect in vivo tumor induction.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
67404 ILLKIRCH GRAFFENSTADEN
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.